2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N12511
    Aristoquinoline 2720562-34-3 98%
    Aristoquinoline (Compound 1) is an alkaloid can be isolated from Aristotelia chilensis. Aristoquinoline has α3β4 nAChR inhibitory activity.
    Aristoquinoline
  • HY-N12566
    Erinacin B 156101-10-9 98%
    Erinacin B is a active product that can be extracts from the mycelia of Hericium erinaceum. Erinacin B shows potent stimulating activity of nerve growth factor (NGF)-synthesis.
    Erinacin B
  • HY-N12581
    Kuwanon U 123702-95-4 98%
    Kuwanon U is a potent cholinesterase inhibitor with IC50s of 19.69, 10.11 µM and Kis of 6.48, 9.59 µM for acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), respectively. Kuwanon U has the potential for the research of Alzheimer’s disease (AD).
    Kuwanon U
  • HY-N12605
    hTRPA1-IN-1 98%
    hTRPA1-IN-1 (19), a norsesterterpenoid that can be isolated from the Marine Sponge Diacarnus spinipoculum, is an inhibitor of transient receptor potential Ankyrin 1 (TRPA1), with an IC50 of 2 μM.
    hTRPA1-IN-1
  • HY-N12622
    AChE-IN-58 98%
    AChE-IN-58 (Compound 3) is an acetylcholinesterase (AChE) inhibitor. AChE-IN-58 can extend the mean lifespan, delay the Aβ1-42-induced paralysis, enhanc the locomotion, and alleviate glutamic acid (Glu)-induced neurotoxicity of CL4176 worms.
    AChE-IN-58
  • HY-N12635
    Levinoid C 98%
    Levinoid C is a Cytochrome P450-modified bacterial terpenoid. Levinoid C shows moderate neuroprotective activity against glutamate-induced excitotoxicity cell model with an EC50 of 21 μM.
    Levinoid C
  • HY-N12657
    Retinestatin 98%
    Retinestatin, a new polyol polyketide, can protect SH-SY5Y dopaminergic cells from MPP+ (HY-W008719)-induced cytotoxicity. Retinestatin shows neuroprotective effects in an in vitro model of Parkinson’s disease.
    Retinestatin
  • HY-N12669
    Curcumin monoglucoside 387818-26-0 98%
    Curcumin monoglucoside is a flavonoid derivative possessing antioxidant, anti-apoptotic, neuroprotective effects, and antibacterial activity. Curcumin monoglucoside can be used in research on Parkinson's disease.
    Curcumin monoglucoside
  • HY-N12715
    Valerena-4,7(11)-diene 351222-66-7 98%
    Valerena-4,7(11)-diene is a tranquilizer. Valerena-4,7(11)-diene suppresses stress-induced excitatory behaviors. Valerena-4,7(11)-diene is expressed via olfactory stimulation and pulmonary absorption.
    Valerena-4,7(11)-diene
  • HY-N12812
    Tenuifoliose J 147742-15-2 98%
    Tenuifoliose J is a neuroprotective oligosaccharide. Tenuifoliose J protects SY5Y cells induced by corticosterone (HY-B1618).
    Tenuifoliose J
  • HY-N12814
    Tenuifoliose C 139682-03-4 98%
    Tenuifoliose C is an oligosaccharide that can be isolated from Polygala tenuifolia, used in neural-related research.
    Tenuifoliose C
  • HY-N13088
    Hyperidione D 98%
    Hyperidione D is apotent antidepressant agent. Hyperidione D shows neuroprotective effects.
    Hyperidione D
  • HY-N1318S
    Salvigenin-d9 98%
    Salvigenin-d9 is the deuterium labeled Salvigenin. Salvigenin is a natural polyphenolic compound, with neuroprotective effect. Salvigenin has antitumor cytotoxic and immunomodulatory properties.
    Salvigenin-d9
  • HY-N13227
    Valerian Extract 98%
    Valerian Extract is a valerian extract. Valerian Extract has potential sedative and anxiolytic effects..
    Valerian Extract
  • HY-N13232
    Grape Skin Extract 98%
    Grape Skin Extract is a grape skin extract, and its ingredients include: Polyphenols. Grape Skin Extract has neuroprotective effects and can improve Aβ-induced cytotoxicity to SH-SY5Y cells. Grape Skin Extract can increase the proliferation and memory of neurogenic areas, but reduce the oxidative stress associated with proinflammatory cytokines during aging, thereby protecting neurons..
    Grape Skin Extract
  • HY-N13251
    Verbena Extract 98%
    Verbena Extract is a verbena extract. Verbena Extract is a potential anti-ischemic stroke agent, and its mechanism may be related to IL17A-mediated neuroinflammation regulation..
    Verbena Extract
  • HY-N13361
    Elodeoidileon A 98%
    Elodeoidileon A is an agonist for RXRα, that interacts with RXRα-LBD protein with a dissociation constant Kd of 5.85 μM. Elodeoidileon A promotes the expression of ATP-binding cassette transporter A1 (ABCA1). Elodeoidileon A reveals the potential in Alzheimer's disease research.
    Elodeoidileon A
  • HY-N13380
    6′‐O‐Galloylsalidroside 83013-86-9 98%
    6’-O-Galloylsalidroside is an active component of Rhodiola. 6’-O-Galloylsalidroside is promising for research of Alzheimer’s disease, lung diseases, cerebrovascular disease, diabetes, cardiovascular disease and aging-related diseases.
    6′‐O‐Galloylsalidroside
  • HY-N1363R
    Royal Jelly acid (Standard) 14113-05-4
    Royal Jelly acid (Standard) is the analytical standard of Royal Jelly acid. This product is intended for research and analytical applications. Royal Jelly acid (Queen Bee Acid) is a fatty acid constituent of royal jelly, promotes the growth and protection of neurons, reduces anxiety-like phenotypes.
    Royal Jelly acid (Standard)
  • HY-N1378R
    (E)-Cardamonin (Standard) 19309-14-9
    (E)-Cardamonin (Standard) is the analytical standard of (E)-Cardamonin. This product is intended for research and analytical applications. (E)-Cardamonin ((E)-Cardamomin) is a novel antagonist of hTRPA1 cation channel with an IC50 of 454 nM.
    (E)-Cardamonin (Standard)
Cat. No. Product Name / Synonyms Application Reactivity